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Medicine prices in South Africa

Sertraline Price in South Africa (2026)

Compiled by the TrustClinix data team · Medical review pending3 official sourcesPrices last checked 25 October 2026How we get our data
Lowest Single Exit Price (SEP) per tablet
R2.69

Cheapest 50 mg tablet: TRALIDEP 50, R80.78 for 30 tablets. Official SEP list, Oct 2026.

≈ $0.16 per tablet
R80.78
cheapest pack (30 tablets)
R80.78
30 tablets (1 a day for a month)
21
listed products
SEP
price type
What you actually pay

What a patient pays for sertraline in South Africa

R80.78
official SEP for TRALIDEP 50, 30 tablets
+ R69.33
maximum dispensing fee incl. VAT
Up to R150
you pay at the pharmacy

Single Exit Price plus the maximum pharmacist dispensing fee and VAT on the fee. Medical schemes may pay part.

21 products

21 different brand names across 2 strengths are on the official list.

7.1× spread

For 50 mg tablet, the priciest tablet (Zoloft Tablets 50mg) costs 7.1 times the cheapest (TRALIDEP 50).

2.7× for the original

The originator brand Sertra Tablets 50mg costs R7.36 per tablet; the cheapest generic, TRALIDEP 50, costs R2.69.

India

has the lowest listed price per tablet for the same strength: $0.020 vs $0.16 here (different price types; see below).

Interactive

How much will Sertraline 50 mg tablet cost you?

tablets per day: 1 a day
Supply
30 days90 days1 year

Your doctor decides how many tablets you need. This is a cost estimate only, using R2.69 per tablet.

Estimated cost
R80.78
For a full yearR983
Per tablet in USD$0.162
Every listed product

All 21 sertraline products in South Africa

Sertraline official prices in South Africa
ProductStrength and formPackPricePer unit
TRALIDEP 5050 mg tablet30 tabletsR80.78R2.69
Dyna Sertraline 5050 mg film-coated tablet30 tabletsR92.90R3.10
Serlife 5050 mg tablet30 tabletsR104R3.47
Serdep-5050 mg tablet30 tabletsR119R3.98
Zylin 5050 mg film-coated tablet30 tabletsR127R4.24
Arysert 5050 mg tablet30 tabletsR128R4.27
Zolid 50 mg50 mg tablet30 tabletsR143R4.76
Sertraline-Winthrop 50 mg50 mg film-coated tablet30 tabletsR177R5.91
Arrow Sertraline 5050 mg tablet30 tabletsR207R6.90
Sertra Tablets 50mg original50 mg tablet30 tabletsR221R7.36
Zosert 5050 mg tablet30 tabletsR326R10.88
Sermax 5050 mg tablet30 tabletsR349R11.65
Zoloft Tablets 50mg original50 mg film-coated tablet30 tabletsR578R19.25
TRALIDEP 100100 mg tablet30 tabletsR86.15R2.87
Dyna Sertraline 100100 mg film-coated tablet30 tabletsR99.07R3.30
Serlife 100100 mg tablet30 tabletsR111R3.70
Serdep 100100 mg tablet30 tabletsR151R5.04
Zolid 100 mg100 mg tablet30 tabletsR176R5.86
Austell Setraline 100 Mg100 mg tablet30 tabletsR301R10.02
Arrow Sertraline 100100 mg tablet30 tabletsR412R13.74
Sermax 100100 mg tablet30 tabletsR623R20.76
TRALIDEP 50R2.69
Dyna Sertraline 50R3.10
Serlife 50R3.47
Serdep-50R3.98
Zylin 50R4.24
Arysert 50R4.27
Zolid 50 mgR4.76
Sertraline-Winthrop 50 mgR5.91
Arrow Sertraline 50R6.90
Sertra Tablets 50mgR7.36
Sertraline 50 mg tablet: price per tablet by product (ZAR)
Same medicine, other countries

Sertraline 50 mg tablet: South Africa vs 5 other countries

India$0.020
United States$0.035
United Kingdom$0.048
Australia$0.058
United Arab Emirates$0.11
South Africa (this page)$0.16
Lowest listed price per tablet (USD)
By country
CountryPrice typePer tablet (local)Per unit (USD)
IndiaJan Aushadhi MRP₹1.86$0.020
United StatesNADAC pharmacy acquisition cost$0.035$0.035
United KingdomNHS Drug Tariff price£0.036$0.048
AustraliaPBS approved ex-manufacturer priceA$0.083$0.058
United Arab EmiratesAbu Dhabi DoH public priceAED 0.41$0.11

Countries publish different kinds of price (manufacturer, reimbursement or retail), so differences are partly due to what is measured. Converted at official US dollar pegs (AED, SAR) and ECB reference rates of 23 October 2026.

What this price means

How SEPs work in South Africa

Prices on this page are the Single Exit Price: the one legal price at which the manufacturer may sell the pack in South Africa, including VAT and a logistics fee. Pharmacies and dispensing doctors add a regulated dispensing fee plus VAT on top. For cheap medicines this fee is a large share of what you pay, and can be more than the medicine itself, so the counter price can be much higher than the SEP. Medical schemes may pay all or part of it.

Read the full guide to medicine prices in South Africa.

Strengths and forms

Every strength and form of sertraline in South Africa

Strengths and forms
Strength and formProductsCheapest packCheapest per unit
50 mg tablet13R80.78R2.69
100 mg tablet8R86.15R2.87

Different strengths and forms (for example slow-release or dissolving tablets) are not interchangeable without your doctor's advice.

Brand names

Brands of sertraline in South Africa

11 brand names of sertraline are on the official list in South Africa. Each brand page shows every pack and the cheapest alternative with the same strength.

Who supplies it

Sertraline manufacturers in South Africa

The official list names 12 manufacturers for sertraline in South Africa: Trinity Pharma (Pty) Ltd, Pharma Dynamics (Pty) Ltd, Ranbaxy Pharmaceuticals (Pty) Ltd, Cipla Medpro (Pty) Ltd, Zydus Healthcare SA (Pty) Ltd, Unimed Healthcare (Pty) Ltd, Zentiva South Africa (Pty) Ltd-Midrand and Arrow Pharma South Africa (Pty) Ltd and 4 more.

A–Z

Other medicine prices in South Africa

Keep exploring

What people check next

Quick answers

Frequently asked questions

How much does sertraline cost in South Africa?
Official SEPs for sertraline in South Africa range from R80.78 to R623 per pack across 21 listed products. The cheapest 50 mg tablet works out at R2.69 each (about $0.16).
What kind of price is this?
It is the Single Exit Price: the one legal price at which the manufacturer may sell the pack in South Africa, including VAT and a logistics fee. Pharmacies and dispensing doctors add a regulated dispensing fee plus VAT on top. For cheap medicines this fee is a large share of what you pay, and can be more than the medicine itself, so the counter price can be much higher than the SEP. Medical schemes may pay all or part of it.
How much will I pay for sertraline at a pharmacy in South Africa?
Up to R150 for TRALIDEP 50 (30 tablets). Single Exit Price plus the maximum pharmacist dispensing fee and VAT on the fee. Medical schemes may pay part.
What is the cheapest sertraline 50 mg tablet in South Africa?
TRALIDEP 50 at R80.78 for 30 tablets, or R2.69 per tablet. 12 other products have the same strength.
What brands of sertraline are sold in South Africa?
11 brand names are on the official list, including Tralidep (from R80.78), Serlife (from R104), Zylin (from R127), Arysert (from R128) and Zolid (from R143).
Who makes sertraline sold in South Africa?
Manufacturers named on the official list include Trinity Pharma (Pty) Ltd, Pharma Dynamics (Pty) Ltd, Ranbaxy Pharmaceuticals (Pty) Ltd and Cipla Medpro (Pty) Ltd.
Is sertraline cheaper in other countries?
For 50 mg tablet, the lowest listed price per tablet is $0.020 in India, $0.035 in the United States, $0.048 in the United Kingdom and $0.058 in Australia, compared with $0.16 in South Africa. Each country publishes a different type of price, so treat this as a rough guide.
Evidence

Sources

  1. National Department of Health, South Africa. Database of Medicine Prices (Single Exit Price), effective 1 October 2026. www.health.gov.za/nhi-pee/. Retrieved 25 October 2026.
  2. National Department of Health, South Africa. Dispensing fee for pharmacists (Notice 5364, Government Gazette 51352, 4 October 2024): maximum fee by SEP band, excluding VAT. archive.gazettes.africa/archive/za/2024/za-government-gazette-dated-20. Retrieved 25 October 2026.
  3. European Central Bank. Euro foreign exchange reference rates (2026-10-23). www.ecb.europa.eu/stats/eurofxref/eurofxref-daily.xml. Retrieved 25 October 2026.

Important: These are published reference prices and estimates, not a quote, and not medical advice. Actual costs depend on the hospital, your health, the exact treatment and your insurance. Always confirm the price with the provider before treatment. Read our disclaimer · Report an error