Methotrexate Price in the United States (2026)
Average pharmacy cost for generic methotrexate 2.5 mg tablet, across 17 product codes (NDCs). CMS NADAC file, Oct 2026.
≈ $0.16 per tabletMethotrexate cost without insurance
The figures here are what US retail pharmacies pay for generic methotrexate: about $0.16 per tablet (2.5 mg tablet), so $4.90 for a 30-day supply at one a day. If you pay cash, the pharmacy adds a dispensing fee and its margin, so expect to pay more than this, and prices differ between pharmacies for the same prescription.
With insurance or Medicare Part D you usually pay a fixed co-pay or co-insurance instead. Ask for the generic rather than the brand, compare a few pharmacies, and check discount programs: for cheap generics a cash price can be lower than your co-pay.
One product name across 3 strengths are on the official list.
has the lowest listed price per tablet for the same strength: $0.016 vs $0.16 here (different price types; see below).
How much will Methotrexate 2.5 mg tablet cost you?
All 3 methotrexate products in the United States
| Generic (NADAC description) | Strength | Form | Per unit | 30 units |
|---|---|---|---|---|
| methotrexate 2.5 mg tablet | 2.5 mg | tablet | $0.16 | $4.90 |
| methotrexate 50 mg/2 mL vial | 50 mg | injection | $1.75 | $52.50 |
| methotrexate 250 mg/10 mL vial | 250 mg | injection | $0.70 | $21.06 |
Methotrexate 2.5 mg tablet: the United States vs 5 other countries
| Country | Price type | Per tablet (local) | Per unit (USD) |
|---|---|---|---|
| India | Jan Aushadhi MRP | ₹1.50 | $0.016 |
| United Kingdom | NHS Drug Tariff price | £0.053 | $0.071 |
| South Africa | Single Exit Price (SEP) | R1.56 | $0.094 |
| Australia | PBS approved ex-manufacturer price | A$0.16 | $0.11 |
| United Arab Emirates | Abu Dhabi DoH public price | AED 0.78 | $0.21 |
Countries publish different kinds of price (manufacturer, reimbursement or retail), so differences are partly due to what is measured. Converted at official US dollar pegs (AED, SAR) and ECB reference rates of 23 October 2026.
How NADAC prices work in the United States
Prices on this page are the National Average Drug Acquisition Cost (NADAC): the average price US retail pharmacies pay wholesalers for the drug, per tablet, capsule, mL or gram, from a monthly survey run for the Centers for Medicare & Medicaid Services (CMS). It is not the price on your receipt. Pharmacies add a dispensing fee and a margin, so the cash price without insurance is higher, often much higher, while your co-pay with insurance depends on your plan. Discount programs and low-cost pharmacies often sell common generics close to this cost plus a fee.
Read the full guide to medicine prices in the United States.
Every strength and form of methotrexate in the United States
| Strength and form | Products | Cheapest pack | Cheapest per unit |
|---|---|---|---|
| 2.5 mg tablet | 1 | $0.16 | $0.16 |
| 50 mg injection | 1 | $1.75 | — |
| 250 mg injection | 1 | $0.70 | — |
Different strengths and forms (for example slow-release or dissolving tablets) are not interchangeable without your doctor's advice.
Other medicine prices in the United States
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- Metformin and Sitagliptin price5 productsfrom $2.51
- Methadone price4 productsfrom $0.16
- Methocarbamol price3 productsfrom $0.039
- Methylergonovine price1 productfrom $5.07
- Methylphenidate price38 productsfrom $0.080
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What people check next
Frequently asked questions
How much does methotrexate cost in the United States?
What kind of price is this?
What is the cheapest methotrexate 2.5 mg tablet in the United States?
How much does methotrexate cost without insurance?
Is NADAC the retail price of methotrexate?
Is methotrexate cheaper in other countries?
Sources
- Centers for Medicare & Medicaid Services (CMS). NADAC (National Average Drug Acquisition Cost) 2026, weekly file as of 28 October 2026 (generic prescription drugs). data.medicaid.gov/dataset/fbb83258-11c7-47f5-8b18-5f8e79f7e704. Retrieved 31 October 2026.
- European Central Bank. Euro foreign exchange reference rates (2026-10-23). www.ecb.europa.eu/stats/eurofxref/eurofxref-daily.xml. Retrieved 25 October 2026.
Important: These are published reference prices and estimates, not a quote, and not medical advice. Actual costs depend on the hospital, your health, the exact treatment and your insurance. Always confirm the price with the provider before treatment. Read our disclaimer · Report an error