Methotrexate Price in South Africa (2026)
Cheapest 2.5 mg tablet: Methotrexate Lederle 2.5, R156 for 100 tablets. Official SEP list, Oct 2026.
≈ $0.094 per tabletWhat a patient pays for methotrexate in South Africa
Single Exit Price plus the maximum pharmacist dispensing fee and VAT on the fee. Medical schemes may pay part.
5 different brand names across 3 strengths are on the official list.
For 2.5 mg tablet, the priciest tablet (Abitrexate 2,5 mg Tablets) costs 1.1 times the cheapest (Methotrexate Lederle 2.5).
has the lowest listed price per tablet for the same strength: $0.016 vs $0.094 here (different price types; see below).
How much will Methotrexate 2.5 mg tablet cost you?
All 5 methotrexate products in South Africa
| Product | Strength and form | Pack | Price | Per unit |
|---|---|---|---|---|
| Methotrexate Lederle 2.5 original | 2.5 mg tablet | 100 tablets | R156 | R1.56 |
| Mexate | 2.5 mg tablet | 100 tablets | R157 | R1.57 |
| Abitrexate 2,5 mg Tablets | 2.5 mg tablet | 100 tablets | R173 | R1.73 |
| Methacor 25mg/ml | 25 mg/ml injection | 2 | R38.64 | — |
| Abitrexate 5 g | 5 g injection | 50 | R4,512 | — |
Methotrexate 2.5 mg tablet: South Africa vs 5 other countries
| Country | Price type | Per tablet (local) | Per unit (USD) |
|---|---|---|---|
| India | Jan Aushadhi MRP | ₹1.50 | $0.016 |
| United Kingdom | NHS Drug Tariff price | £0.053 | $0.071 |
| Australia | PBS approved ex-manufacturer price | A$0.16 | $0.11 |
| United States | NADAC pharmacy acquisition cost | $0.16 | $0.16 |
| United Arab Emirates | Abu Dhabi DoH public price | AED 0.78 | $0.21 |
Countries publish different kinds of price (manufacturer, reimbursement or retail), so differences are partly due to what is measured. Converted at official US dollar pegs (AED, SAR) and ECB reference rates of 23 October 2026.
How SEPs work in South Africa
Prices on this page are the Single Exit Price: the one legal price at which the manufacturer may sell the pack in South Africa, including VAT and a logistics fee. Pharmacies and dispensing doctors add a regulated dispensing fee plus VAT on top. For cheap medicines this fee is a large share of what you pay, and can be more than the medicine itself, so the counter price can be much higher than the SEP. Medical schemes may pay all or part of it.
Every strength and form of methotrexate in South Africa
| Strength and form | Products | Cheapest pack | Cheapest per unit |
|---|---|---|---|
| 2.5 mg tablet | 3 | R156 | R1.56 |
| 25 mg injection | 1 | R38.64 | — |
| 5000 mg injection | 1 | R4,512 | — |
Different strengths and forms (for example slow-release or dissolving tablets) are not interchangeable without your doctor's advice.
Brands of methotrexate in South Africa
3 brand names of methotrexate are on the official list in South Africa. Each brand page shows every pack and the cheapest alternative with the same strength.
Methotrexate manufacturers in South Africa
The official list names 4 manufacturers for methotrexate in South Africa: Pfizer Laboratories (Pty) Ltd, Zydus Healthcare SA (Pty) Ltd, Teva Pharmaceuticals (Pty) Ltd and Accord Healthcare (Pty) Ltd.
Other medicine prices in South Africa
- Metformin and Sitagliptin price9 productsfrom R167
- Metformin and Vildagliptin price21 productsfrom R89.51
- Methadone price10 productsfrom R76.84
- Methocarbamol price8 productsfrom R63.18
- Methotrexate Solution price6 productsfrom R33.80
- Methoxsalen price1 productfrom R2,589
- Methoxy Polythylene Glycol-Epoetin Beta price2 productsfrom R3,547
- Methoxyflurane price1 productfrom R639
What people check next
Frequently asked questions
How much does methotrexate cost in South Africa?
What kind of price is this?
How much will I pay for methotrexate at a pharmacy in South Africa?
What is the cheapest methotrexate 2.5 mg tablet in South Africa?
What brands of methotrexate are sold in South Africa?
Who makes methotrexate sold in South Africa?
Is methotrexate cheaper in other countries?
Sources
- National Department of Health, South Africa. Database of Medicine Prices (Single Exit Price), effective 1 October 2026. www.health.gov.za/nhi-pee/. Retrieved 25 October 2026.
- National Department of Health, South Africa. Dispensing fee for pharmacists (Notice 5364, Government Gazette 51352, 4 October 2024): maximum fee by SEP band, excluding VAT. archive.gazettes.africa/archive/za/2024/za-government-gazette-dated-20. Retrieved 25 October 2026.
- European Central Bank. Euro foreign exchange reference rates (2026-10-23). www.ecb.europa.eu/stats/eurofxref/eurofxref-daily.xml. Retrieved 25 October 2026.
Important: These are published reference prices and estimates, not a quote, and not medical advice. Actual costs depend on the hospital, your health, the exact treatment and your insurance. Always confirm the price with the provider before treatment. Read our disclaimer · Report an error