Medicine prices in South Africa
Esomeprazole Price in South Africa (2026)
Compiled by the TrustClinix data team · Medical review pending3 official sourcesPrices last checked 25 October 2026How we get our data
Lowest Single Exit Price (SEP) per tablet
R4.03
Cheapest 20 mg tablet: Nextell OTC, R56.42 for 14 tablets. Official SEP list, Oct 2026.
≈ $0.24 per tabletR56.42
cheapest pack (14 tablets)
R121
30 tablets (1 a day for a month)
74
listed products
SEP
price type
What you actually pay
What a patient pays for esomeprazole in South Africa
R56.42
official SEP for Nextell OTC, 14 tablets
+ R56.45
maximum dispensing fee incl. VAT
Up to R113
you pay at the pharmacy
Single Exit Price plus the maximum pharmacist dispensing fee and VAT on the fee. Medical schemes may pay part.
74 products
55 different brand names across 4 strengths are on the official list.
4.9× spread
For 20 mg tablet, the priciest tablet (Nexiam 20mg) costs 4.9 times the cheapest (Nextell OTC).
4.9× for the original
The originator brand Nexiam 20 Mg costs R19.88 per tablet; the cheapest generic, Nextell OTC, costs R4.03.
United Kingdom
has the lowest listed price per tablet for the same strength: $0.093 vs $0.24 here (different price types; see below).
Interactive
How much will Esomeprazole 20 mg tablet cost you?
Every listed product
All 74 esomeprazole products in South Africa
| Product | Strength and form | Pack | Price | Per unit |
|---|---|---|---|---|
| Nextell OTC | 20 mg film-coated tablet | 14 tablets | R56.42 | R4.03 |
| Trusfluks 20 | 20 mg tablet | 28 tablets | R186 | R6.65 |
| NEXILOK 20 | 20 mg film-coated tablet | 14 tablets | R111 | R7.90 |
| Esocid 20 | 20 mg tablet | 14 tablets | R113 | R8.04 |
| Truloc 20 mg | 20 mg tablet | 14 tablets | R114 | R8.13 |
| Truloc 20 mg | 20 mg tablet | 30 tablets | R244 | R8.13 |
| Nexgastro 20 | 20 mg film-coated tablet | 14 tablets | R117 | R8.36 |
| Omiflynt | 20 mg tablet | 14 tablets | R118 | R8.45 |
| Fluxtrin 20 | 20 mg tablet | 30 tablets | R255 | R8.49 |
| Fluxtrin OTC | 20 mg tablet | 14 tablets | R120 | R8.57 |
| Jubigord 20 | 20 mg tablet | 14 tablets | R125 | R8.95 |
| Jubigord 20 | 20 mg tablet | 30 tablets | R269 | R8.95 |
| NEXILOK 20 | 20 MG film-coated tablet | 28 tablets | R252 | R9.01 |
| Nectizole OTC 20 | 20 mg tablet | 14 tablets | R127 | R9.04 |
| Nectizole OTC 20 | 20 mg tablet | 7 tablets | R63.27 | R9.04 |
| NEXES OTC | 20 mg tablet | 14 tablets | R133 | R9.48 |
| Nectizole 20 | 20 mg tablet | 30 tablets | R287 | R9.56 |
| Esomeprazole 20 Unicorn | 20 mg tablet | 14 tablets | R135 | R9.61 |
| Esomeprazole 20 Unicorn | 20 mg tablet | 28 tablets | R269 | R9.61 |
| NEXIPRAZ OTC | 20 mg tablet | 7 tablets | R67.30 | R9.61 |
| NEXIPRAZ OTC | 20 mg tablet | 14 tablets | R135 | R9.61 |
| Nextell 20 mg | 20 mg tablet | 28 tablets | R277 | R9.91 |
| Esomeprazole 20 mg Cipla | 20 mg film-coated tablet | 28 tablets | R277 | R9.91 |
| Nesopram 20 | 20 mg tablet | 30 tablets | R304 | R10.12 |
| Peptimep 20 | 20 mg tablet | 30 tablets | R320 | R10.66 |
| Nexipraz 20 | 20 mg tablet | 30 tablets | R325 | R10.83 |
| Nexiflux 20 | 20 mg tablet | 14 tablets | R154 | R11.01 |
| Nexiflux 20 | 20 mg tablet | 28 tablets | R308 | R11.01 |
| Nexiflux 20 | 20 mg tablet | 30 tablets | R330 | R11.01 |
| Nexomep 20 | 20 mg tablet | 28 tablets | R310 | R11.06 |
| Trustan 20mg | 20 mg tablet | 28 tablets | R316 | R11.27 |
| Trustan 20mg | 20 mg tablet | 14 tablets | R158 | R11.27 |
| Nexiam 20 Mg original | 20 mg tablet | 14 tablets | R278 | R19.88 |
| Nexiam 20mg original | 20 mg tablet | 28 tablets | R557 | R19.88 |
| NECTIZOLE IV | 40 mg infusion | 5 | R30.75 | — |
| Esomeprazole 40 IV Cipla | 40 mg injection | 5 | R32.37 | — |
| ESOMEPRAZOLE 40 MG COSPHARM | 40 MG injection | 1 | R38.63 | — |
| NECTIZOLE IV | 40 mg infusion | 25 | R154 | — |
| Hetenex 40 Injection | 40 mg injection | 50 | R248 | — |
| Nexipraz IV | 40 mg injection | 50 | R269 | — |
| Truloc IV 40 mg | 40 mg injection | 10 | R318 | — |
| Esomeprazole 40 IV Cipla | 40 mg injection | 50 | R324 | — |
| Mitogut 40 | 40 mg injection | 50 | R474 | — |
| Aspepraz 40mg Injection | 40 mg injection | 50 | R617 | — |
| Nexiam 40mg IV original | 40 mg injection | 50 | R1,073 | — |
| Esomeprazole 10 Granules Cipla | 10 mg sac | 30 | R418 | — |
| Nexiam 2.5Mg Sachets original | granules | 28 | R531 | — |
| Nexiam 5Mg Sachets original | 5 mg granules | 28 | R531 | — |
| Nexiam 10Mg Sachets original | 10 mg granules | 28 | R531 | — |
| Hetenex 40 Injection | 40 mg film-coated tablet | 5 tablets | R24.85 | R4.97 |
| Hetenex 40 Injection | 40 mg film-coated tablet | 25 tablets | R124 | R4.97 |
| Trusfluks 40 | 40 mg tablet | 28 tablets | R264 | R9.43 |
| Truloc 40 mg | 40 mg tablet | 14 tablets | R172 | R12.29 |
| Truloc 40 mg | 40 mg tablet | 30 tablets | R369 | R12.30 |
| Jubigord 40 | 40 mg tablet | 30 tablets | R386 | R12.85 |
| Fluxtrin 40 | 40 mg tablet | 30 tablets | R396 | R13.19 |
| NEXILOK 40 | 40 MG film-coated tablet | 28 tablets | R378 | R13.51 |
| Esomeprazole 40 Unicorn | 40 mg tablet | 28 tablets | R397 | R14.17 |
| Nextell 40 mg | 40 mg tablet | 28 tablets | R399 | R14.25 |
| Nectizole 40 | 40 mg tablet | 30 tablets | R428 | R14.25 |
| Esomeprazole 40 mg Cipla | 40 mg film-coated tablet | 28 tablets | R399 | R14.25 |
| Nesopram 40 | 40 mg tablet | 30 tablets | R460 | R15.32 |
| Nexipraz 40 | 40 mg tablet | 30 tablets | R491 | R16.38 |
| Peptimep 40 | 40 mg tablet | 30 tablets | R493 | R16.44 |
| Nexomep 40 | 40 mg tablet | 28 tablets | R469 | R16.75 |
| Nexiflux 40 | 40 mg tablet | 30 tablets | R508 | R16.94 |
| Nexiflux 40 | 40 mg tablet | 14 tablets | R237 | R16.95 |
| Nexiflux 40 | 40 mg tablet | 28 tablets | R475 | R16.95 |
| Nexmezol 40 | 40 mg tablet | 14 tablets | R238 | R17.04 |
| Nexmezol 40 | 40 mg tablet | 28 tablets | R477 | R17.04 |
| Trustan 40mg | 40 mg tablet | 14 tablets | R242 | R17.28 |
| Trustan 40mg | 40 mg tablet | 28 tablets | R484 | R17.28 |
| Nexiam 40 Mg original | 40 mg tablet | 14 tablets | R429 | R30.66 |
| Nexiam 40 Mg original | 40 mg tablet | 28 tablets | R859 | R30.66 |
Same medicine, other countries
Esomeprazole 20 mg tablet: South Africa vs 3 other countries
| Country | Price type | Per tablet (local) | Per unit (USD) |
|---|---|---|---|
| United Kingdom | NHS Drug Tariff price | £0.070 | $0.093 |
| Australia | PBS approved ex-manufacturer price | A$0.13 | $0.094 |
| United Arab Emirates | Abu Dhabi DoH public price | AED 1.18 | $0.32 |
Countries publish different kinds of price (manufacturer, reimbursement or retail), so differences are partly due to what is measured. Converted at official US dollar pegs (AED, SAR) and ECB reference rates of 23 October 2026.
What this price means
How SEPs work in South Africa
Prices on this page are the Single Exit Price: the one legal price at which the manufacturer may sell the pack in South Africa, including VAT and a logistics fee. Pharmacies and dispensing doctors add a regulated dispensing fee plus VAT on top. For cheap medicines this fee is a large share of what you pay, and can be more than the medicine itself, so the counter price can be much higher than the SEP. Medical schemes may pay all or part of it.
Other medicines with esomeprazole
Combinations containing esomeprazole in South Africa
Strengths and forms
Every strength and form of esomeprazole in South Africa
| Strength and form | Products | Cheapest pack | Cheapest per unit |
|---|---|---|---|
| 20 mg tablet | 34 | R56.42 | R4.03 |
| 40 mg tablet | 25 | R24.85 | R4.97 |
| 40 mg injection | 11 | R30.75 | — |
| 10 mg other | 1 | R418 | — |
| powder | 1 | R531 | — |
| 5 mg powder | 1 | R531 | — |
| 10 mg powder | 1 | R531 | — |
Different strengths and forms (for example slow-release or dissolving tablets) are not interchangeable without your doctor's advice.
Brand names
Brands of esomeprazole in South Africa
29 brand names of esomeprazole are on the official list in South Africa. Each brand page shows every pack and the cheapest alternative with the same strength.
- Hetenex price3 packsfrom R24.85
- Nectizole Iv price2 packsfrom R30.75
- Nextell Otc price1 packfrom R56.42
- Nectizole Otc price2 packsfrom R63.27
- Nexipraz Otc price2 packsfrom R67.30
- Nexilok price3 packsfrom R111
- Esocid price1 packfrom R113
- Truloc price4 packsfrom R114
- Nexgastro price1 packfrom R117
- Omiflynt price1 packfrom R118
- Fluxtrin Otc price1 packfrom R120
- Jubigord price3 packsfrom R125
- Nexes Otc price1 packfrom R133
- Nexiflux price6 packsfrom R154
- Trustan price4 packsfrom R158
- Trusfluks price2 packsfrom R186
- Nexmezol price2 packsfrom R238
- Fluxtrin price2 packsfrom R255
- Nexipraz Iv price1 packfrom R269
- Nextell price2 packsfrom R277
- Nexiam price8 packsfrom R278
- Nectizole price2 packsfrom R287
- Nesopram price2 packsfrom R304
- Nexomep price2 packsfrom R310
Who supplies it
Esomeprazole manufacturers in South Africa
The official list names 23 manufacturers for esomeprazole in South Africa: Austell Pharmaceuticals (Pty) Ltd, Innovata Pharmaceuticals (Pty) Ltd, Teva Pharmaceuticals (Pty) Ltd, Zydus Healthcare SA (Pty) Ltd, Pharma Dynamics (Pty) Ltd, Cipla Medpro (Pty) Ltd, Sandoz SA (Pty) Ltd and Strides Pharma SA (Pty) Ltd and 15 more.
A–Z
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Keep exploring
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Quick answers
Frequently asked questions
How much does esomeprazole cost in South Africa?
Official SEPs for esomeprazole in South Africa range from R56.42 to R1,073 per pack across 74 listed products. The cheapest 20 mg tablet works out at R4.03 each (about $0.24).
What kind of price is this?
It is the Single Exit Price: the one legal price at which the manufacturer may sell the pack in South Africa, including VAT and a logistics fee. Pharmacies and dispensing doctors add a regulated dispensing fee plus VAT on top. For cheap medicines this fee is a large share of what you pay, and can be more than the medicine itself, so the counter price can be much higher than the SEP. Medical schemes may pay all or part of it.
How much will I pay for esomeprazole at a pharmacy in South Africa?
Up to R113 for Nextell OTC (14 tablets). Single Exit Price plus the maximum pharmacist dispensing fee and VAT on the fee. Medical schemes may pay part.
What is the cheapest esomeprazole 20 mg tablet in South Africa?
Nextell OTC at R56.42 for 14 tablets, or R4.03 per tablet. 33 other products have the same strength.
What brands of esomeprazole are sold in South Africa?
29 brand names are on the official list, including Hetenex (from R24.85), Nectizole Iv (from R30.75), Nextell Otc (from R56.42), Nectizole Otc (from R63.27) and Nexipraz Otc (from R67.30).
Who makes esomeprazole sold in South Africa?
Manufacturers named on the official list include Austell Pharmaceuticals (Pty) Ltd, Innovata Pharmaceuticals (Pty) Ltd, Teva Pharmaceuticals (Pty) Ltd and Zydus Healthcare SA (Pty) Ltd.
Is esomeprazole cheaper in other countries?
For 20 mg tablet, the lowest listed price per tablet is $0.093 in the United Kingdom, $0.094 in Australia and $0.32 in the UAE, compared with $0.24 in South Africa. Each country publishes a different type of price, so treat this as a rough guide.
Evidence
Sources
- National Department of Health, South Africa. Database of Medicine Prices (Single Exit Price), effective 1 October 2026. www.health.gov.za/nhi-pee/. Retrieved 25 October 2026.
- National Department of Health, South Africa. Dispensing fee for pharmacists (Notice 5364, Government Gazette 51352, 4 October 2024): maximum fee by SEP band, excluding VAT. archive.gazettes.africa/archive/za/2024/za-government-gazette-dated-20. Retrieved 25 October 2026.
- European Central Bank. Euro foreign exchange reference rates (2026-10-23). www.ecb.europa.eu/stats/eurofxref/eurofxref-daily.xml. Retrieved 25 October 2026.
Important: These are published reference prices and estimates, not a quote, and not medical advice. Actual costs depend on the hospital, your health, the exact treatment and your insurance. Always confirm the price with the provider before treatment. Read our disclaimer · Report an error