| Rabeprazole price in South Africa | 12 | R65.33 | R3.92 | Compare |
| Racecadotril price in South Africa | 3 | R128 | R12.76 | Compare |
| Radium Ra price in South Africa | 1 | R71,766 | — | — |
| Raloxifene price in South Africa | 3 | R706 | R23.53 | Compare |
| Raltegravir price in South Africa | 3 | R373 | R24.07 | Compare |
| Ramipril price in South Africa | 23 | R83.70 | R2.79 | Compare |
| Ramucirumab price in South Africa | 2 | R8,850 | — | — |
| Ranibizumab price in South Africa | 1 | R9,583 | — | — |
| Ranitidine price in South Africa | 31 | R13.03 | R0.84 | Compare |
| Ranolazine price in South Africa | 3 | R389 | R6.48 | Compare |
| Rasagiline price in South Africa | 6 | R401 | R13.79 | Compare |
| Ravulizumab price in South Africa | 2 | R84,748 | — | — |
| Recombinant Factor Viii price in South Africa | 3 | R2,251 | — | — |
| Refined Equine Immunoglobulin price in South Africa | 6 | R905 | — | — |
| Regorafenib price in South Africa | 1 | R60,656 | R722 | Compare |
| Regular Human Insulin price in South Africa | 3 | R396 | — | — |
| Remifentanil price in South Africa | 24 | R63.02 | — | — |
| Repaglinide price in South Africa | 6 | R148 | R3.02 | Compare |
| Reserpine price in South Africa | 1 | R31.36 | R1.12 | — |
| Retapamulin price in South Africa | 1 | R176 | — | — |
| Revefenacin price in South Africa | 1 | R960 | — | — |
| Riamilovir price in South Africa | 1 | R1,331 | R66.57 | — |
| Ribavirin price in South Africa | 1 | R455 | R10.83 | Compare |
| Ribociclib price in South Africa | 1 | R7,136 | R340 | Compare |
| Rifabutin price in South Africa | 1 | R581 | R19.37 | Compare |
| Rifampicin price in South Africa | 7 | R146 | R3.07 | Compare |
| Rifapentine price in South Africa | 2 | R261 | R18.82 | Compare |
| Rifaximin price in South Africa | 1 | R3,904 | R69.72 | Compare |
| Rilpivirine price in South Africa | 1 | R82.74 | R2.76 | Compare |
| Riluzole price in South Africa | 1 | R8,613 | R154 | Compare |
| Risdiplam price in South Africa | 1 | R140,789 | — | Compare |
| Risedronate price in South Africa | 5 | R171 | R42.65 | Compare |
| Risperidone price in South Africa | 77 | R124 | R7.66 | Compare |
| Ritonavir price in South Africa | 5 | R66.60 | R1.22 | Compare |
| Rituximab price in South Africa | 15 | R2,203 | — | — |
| Rivaroxaban price in South Africa | 68 | R296 | R9.86 | Compare |
| Rivastigmine price in South Africa | 6 | R351 | R5.85 | Compare |
| Rizatriptan price in South Africa | 17 | R108 | R119 | Compare |
| Rizatriptan Benzoate price in South Africa | 2 | R155 | R51.65 | — |
| Rocuronium price in South Africa | 13 | R71.25 | — | — |
| Roflumilast price in South Africa | 1 | R767 | R25.56 | Compare |
| Romiplostim price in South Africa | 1 | R8,853 | — | — |
| Ropinirole price in South Africa | 13 | R45.03 | R3.76 | Compare |
| Ropinirole Hci price in South Africa | 5 | R129 | R3.84 | — |
| Ropivacaine price in South Africa | 18 | R60.03 | — | — |
| Rosuvastatin price in South Africa | 98 | R59.16 | R2.96 | Compare |
| Roxadustat price in South Africa | 5 | R3,618 | R301 | Compare |
| Roxithromycin price in South Africa | 4 | R86.11 | R8.61 | Compare |
| Rupatadine price in South Africa | 19 | R79.46 | R7.95 | Compare |
| Ruxolitinib price in South Africa | 3 | R24,961 | R891 | Compare |