Synthroid vs Generic Levothyroxine: Price in the United States (2026)
Compiled by the TrustClinix data team · Medical review pending1 official sourcePrices last checked 25 October 2026How we get our data
41× the price of the generic
Synthroid 50 mcg tablet costs $1.66 per tablet, compared with $0.040 for generic levothyroxine, based on the NADAC pharmacy acquisition cost. For 30 tablets the difference is about $48.66.
| Product | Per tablet | 30 tablets | 365 tablets |
|---|---|---|---|
| Synthroid 50 mcg tablet (brand) | $1.66 | $49.86 | $607 |
| Generic levothyroxine 50 mcg tablet | $0.040 | $1.20 | $14.62 |
NADAC is the average price US pharmacies pay to buy a medicine (as of 21 October 2026). Prices at the pharmacy counter and with insurance differ.
Levothyroxine replaces the thyroid hormone thyroxine in people whose thyroid gland is underactive.
Quick answers
Frequently asked questions
Is Synthroid the same as levothyroxine?
Synthroid is a brand name for levothyroxine. Generic versions contain the same active ingredient at the same strength.
How much more does Synthroid cost than the generic?
Based on NADAC data, Synthroid 50 mcg tablet costs about 41 times as much as generic levothyroxine, a difference of about $48.66 for 30 tablets.
Can I switch from the brand to a generic?
Ask your doctor first. With levothyroxine, changing product can change how much hormone you absorb, so doctors often check a TSH blood test after a switch. Do not change or stop a prescribed medicine without medical advice.
Evidence
Sources
- Centers for Medicare & Medicaid Services (CMS). NADAC (National Average Drug Acquisition Cost) 2026 (as of 2026-10-21). data.medicaid.gov/dataset/fbb83258-11c7-47f5-8b18-5f8e79f7e704. Retrieved 25 October 2026.
Important: These are published reference prices and estimates, not a quote, and not medical advice. Actual costs depend on the hospital, your health, the exact treatment and your insurance. Always confirm the price with the provider before treatment. Read our disclaimer · Report an error